Interaction networks

This page visualizes parts of molecular interaction networks that link genes from the different datasets. Please consult the help page for a description of the different visualization styles and the ways to navigate the networks.

Input/panel gene networks

Visualization Network ID Nodes Edges Input nodes Input genes Panel nodes Panel genes Categories p-value ClusterONE p-value ClusterONE density Top enrichment
bioplex,mentha,string_0.9 filtered_n300_e341_i-p 300 341 205 100144602, 100505495, 146880, 6854, 729867, ABCB1, ABCC3, ABCG1, ADCY4, AFAP1-AS1, AHSA2, AKR1C1, ANKRD29, ANKRD36, ATP8A1, BIRC3, C10orf90, C17orf72, C1orf63, C5, C5orf45, C6orf163, C7orf63, CAPG, CATSPER2, CCDC30, CCDC39, CCRL2, CD248, CD74, CD79B, CD83, CDA, CDH10, CDKL2, CDR1, COL24A1, COL6A6, CPM, CRYGS, CSF3, CXCL12, DCLK1, DDIT4L, DDX47, DIRAS3, DMTF1, DOCK6, EBLN2, EDNRA, EFNB2, EN1, ENPP4, EPHA4, EPHB2, ERV3-1, ESYT3, F2RL1, FABP4, FAM13A-AS1, FAM154B, FAM46C, FAM71F2, FGF7, FHL1, FIBIN, FNDC1, FOXL1, FOXS1, FRAS1, GABBR1, GABRE, GALNT14, GCKR, GDNF-AS1, GHRLOS, GNG11, GNRH1, GOLGA8A GOLGA8B, GOLGA8B, GPM6B, GREM1, GSAP, GSDMB, GSTT2 GSTT2B, GUCY1A2, H2AFY2, HERC2P3, HHIP, HMSD, HTR2A, ICAM2, IFITM1, IFNE, IRF6, ITGA10, JAG1, JUP, KCNAB1, KCNIP3, KCNJ2, KCNJ2-AS1, KCNN3, KCNQ1OT1, KIAA0895, KIAA1217, KIAA1522, KIAA1644, KLF5, KREMEN1, KRT17, LACC1, LHX4, LINC00174, LINC00856, LINC01133, LRRC32, LRRC37A LRRC37A2, LRRC61, LY6G5B, MALAT1, MARCH1, MATR3, MCAM, MEG3, MIR155HG, MMRN2, MSH5, MT1L, MT1X, MYCT1, NBEA, NEAT1, NEDD9, NEIL1, NKTR, NME5, NOX4, NPAS1, NPR3, NR2F1, P2RX6, PABPC1L, PCDH1, PCDH12, PCDH17, PCDHB7, PDZRN3, PER3, PFN1P8, PGF, PLA2G5, PLXNB3, PRKG2, PRRX2, PSMD6-AS2, RAB38, RBM47, RNF128, RNF212, RNFT2, RXFP1, SBSN, SCN8A, SEC31B, SEMA3D, SEMA7A, SFTA1P, SH2D2A, SH3BP5-AS1, SLC7A11, SLC7A11-AS1, SLC9A3R2, SLCO2B1, SNCA, SNCG, SP6, SPEG, SPP1, STARD4-AS1, SUGCT, SULF2, SYNC, TFAP2D, TMC3, TMEM229B, TMEM35, TNFRSF10C, TTC18, TTLL3, TTLL7, TXLNG2P, TXNRD1, UBAP1L, UBE2Q2P1, VAMP1, WDR17, WDR52, WTAPP1, WWC1, ZBED6CL, ZNF117, ZNF300, ZNF702P, ZNF83 96 ADAM12, AKT2, ANGPTL4, APP, BACE1, BCL2, BMP1, CCND2, CD44, CDC42, CDK6, COL10A1, COL1A1, COL3A1, COL4A1, COL4A2, COL5A2, COL5A3, CTNNA3, CTNNBIP1, DES, DNAJB11, DNMT1, DNMT3A, DNMT3B, DSC2, DSG2, DSP, DUSP2, EIF4G1, ESR1, FBN1, FGA, FGB, FGG, FOS, GATA3, GPC3, GRN, GSK3B, HDAC4, HMGA2, IFNG, IL32, ITGA6, ITGB1, JUP, LAMC2, LMNA, LOX, LOXL2, LOXL4, MCL1, MICA, MMP15, MMP2, MMP24, MMP9, MTOR, MYCN, NASP, NCOA3, NID1, NKIRAS2, PDGFA, PDGFB, PDGFC, PDGFRA, PDGFRB, PER1, PIK3CG, PIK3R1, PKP2, PLN, PPP1R13B, PTEN, RAX, RYR2, S100B, SERPINH1, SFPQ, SIRT1, SNAI3, SP1, SPARC, TBX21, TCL1A, TDG, TET1, TET2, TGFB1, TGFB2, TGFB3, TMEM43, TTN, VEGFA 0
    funsimbp filtered_n299_e647_i-p 299 647 204 100144602, 100505495, 146880, 729867, ABCB1, ABCC3, ABCG1, ADCY4, AFAP1-AS1, AHSA2, AKR1C1, ANKRD29, ANKRD36, ATP8A1, BIRC3, C10orf90, C17orf72, C1orf63, C5, C5orf45, C6orf163, C7orf63, CAPG, CATSPER2, CCDC30, CCDC39, CCRL2, CD248, CD74, CD79B, CD83, CDA, CDH10, CDKL2, CDR1, COL24A1, COL6A6, CPM, CRYGS, CSF3, CXCL12, DCLK1, DDIT4L, DDX47, DIRAS3, DMTF1, DOCK6, EBLN2, EDNRA, EFNB2, EN1, ENPP4, EPHA4, EPHB2, ERV3-1, ESYT3, F2RL1, FABP4, FAM13A-AS1, FAM154B, FAM46C, FAM71F2, FGF7, FHL1, FIBIN, FNDC1, FOXL1, FOXS1, FRAS1, GABBR1, GABRE, GALNT14, GCKR, GDNF-AS1, GHRLOS, GNG11, GNRH1, GOLGA8A GOLGA8B, GOLGA8B, GPM6B, GREM1, GSAP, GSDMB, GSTT2 GSTT2B, GUCY1A2, H2AFY2, HERC2P3, HHIP, HMSD, HTR2A, ICAM2, IFITM1, IFNE, IRF6, ITGA10, JAG1, JUP, KCNAB1, KCNIP3, KCNJ2, KCNJ2-AS1, KCNN3, KCNQ1OT1, KIAA0895, KIAA1217, KIAA1522, KIAA1644, KLF5, KREMEN1, KRT17, LACC1, LHX4, LINC00174, LINC00856, LINC01133, LRRC32, LRRC37A LRRC37A2, LRRC61, LY6G5B, MALAT1, MARCH1, MATR3, MCAM, MEG3, MIR155HG, MMRN2, MSH5, MT1L, MT1X, MYCT1, NBEA, NEAT1, NEDD9, NEIL1, NKTR, NME5, NOX4, NPAS1, NPR3, NR2F1, P2RX6, PABPC1L, PCDH1, PCDH12, PCDH17, PCDHB7, PDZRN3, PER3, PFN1P8, PGF, PLA2G5, PLXNB3, PRKG2, PRRX2, PSMD6-AS2, RAB38, RBM47, RNF128, RNF212, RNFT2, RXFP1, SBSN, SCN8A, SEC31B, SEMA3D, SEMA7A, SFTA1P, SH2D2A, SH3BP5-AS1, SLC7A11, SLC7A11-AS1, SLC9A3R2, SLCO2B1, SNCA, SNCG, SP6, SPEG, SPP1, STARD4-AS1, SUGCT, SULF2, SYNC, TFAP2D, TMC3, TMEM229B, TMEM35, TNFRSF10C, TTC18, TTLL3, TTLL7, TXLNG2P, TXNRD1, UBAP1L, UBE2Q2P1, VAMP1, WDR17, WDR52, WTAPP1, WWC1, ZBED6CL, ZNF117, ZNF300, ZNF702P, ZNF83 96 ADAM12, AKT2, ANGPTL4, APP, BACE1, BCL2, BMP1, CCND2, CD44, CDC42, CDK6, COL10A1, COL1A1, COL3A1, COL4A1, COL4A2, COL5A2, COL5A3, CTNNA3, CTNNBIP1, DES, DNAJB11, DNMT1, DNMT3A, DNMT3B, DSC2, DSG2, DSP, DUSP2, EIF4G1, ESR1, FBN1, FGA, FGB, FGG, FOS, GATA3, GPC3, GRN, GSK3B, HDAC4, HMGA2, IFNG, IL32, ITGA6, ITGB1, JUP, LAMC2, LMNA, LOX, LOXL2, LOXL4, MCL1, MICA, MMP15, MMP2, MMP24, MMP9, MTOR, MYCN, NASP, NCOA3, NID1, NKIRAS2, PDGFA, PDGFB, PDGFC, PDGFRA, PDGFRB, PER1, PIK3CG, PIK3R1, PKP2, PLN, PPP1R13B, PTEN, RAX, RYR2, S100B, SERPINH1, SFPQ, SIRT1, SNAI3, SP1, SPARC, TBX21, TCL1A, TDG, TET1, TET2, TGFB1, TGFB2, TGFB3, TMEM43, TTN, VEGFA 0

      Clusters in full networks

      Visualization Network ID Nodes Edges Input nodes Input genes Panel nodes Panel genes Categories p-value ClusterONE p-value ClusterONE density Top enrichment
      bioplex,mentha,string_0.9 cluster_clusterone_c0036_n34_e345 34 345 1 NR2F1 1 SP1 0 5.925108e-02 0.996396 0.615
      • hormone-mediated signaling pathway
      • intracellular receptor signaling pathway
      • transcription from RNA polymerase II promoter
      bioplex,mentha,string_0.9 cluster_clusterone_c0065_n10_e27 10 27 1 ITGA10 1 ITGB1 0 5.701806e-03 0.989602 0.6
      • extracellular matrix organization
      • cell adhesion
      • blood coagulation
      bioplex,mentha,string_0.9 cluster_clusterone_c0128_n10_e28 10 28 1 SPP1 2 PDGFA, PDGFB 0 1.758171e-04 0.992392 0.6222
      • extracellular matrix organization
      • negative regulation of phosphatidylinositol biosynthetic process
      • platelet degranulation
      bioplex,mentha,string_0.9 cluster_clusterone_c0129_n48_e602 48 602 2 C5, CXCL12 0 0 1.073501e-01 0.034511 0.5337
      • G-protein coupled receptor signaling pathway
      • chemotaxis
      • positive regulation of leukocyte chemotaxis
      bioplex,mentha,string_0.9 cluster_clusterone_c0163_n12_e34 12 34 2 GSAP, JAG1 0 0 8.235375e-03 0.988167 0.5152
      • Notch receptor processing
      • Notch signaling pathway
      • cell fate determination
      bioplex,mentha,string_0.9 cluster_clusterone_c0219_n59_e926 59 926 4 EDNRA, F2RL1, GNRH1, HTR2A 0 0 4.936742e-03 0.0138312 0.5412
      • G-protein coupled receptor signaling pathway
      • signal transduction
      • circulatory system process
      bioplex,mentha,string_0.9 cluster_clusterone_c0273_n34_e419 34 419 2 IFITM1, IRF6 0 0 5.925108e-02 0.531829 0.7469
      • defense response
      • immune response
      • immune system process
      bioplex,mentha,string_0.9 cluster_clusterone_c0368_n6_e9 6 9 1 SYNC 1 DES 0 1.959976e-03 0.998089 0.6
      • intermediate filament-based process
      • cytoskeleton organization
      • positive regulation of Schwann cell proliferation
      bioplex,mentha,string_0.9 cluster_clusterone_c0406_n15_e63 15 63 2 CD74, MARCH1 0 0 1.280449e-02 0.994562 0.6
      • antigen processing and presentation of peptide antigen via MHC class II
      • antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
      • antigen processing and presentation
      bioplex,mentha,string_0.9 cluster_clusterone_c0422_n5_e6 5 6 2 6854, DCLK1 0 0 1.316762e-03 0.991847 0.6
      • guanosine metabolic process
      • purine deoxyribonucleoside metabolic process
      • bacterial-type flagellum-dependent cell motility
      bioplex,mentha,string_0.9 cluster_clusterone_c0434_n5_e6 5 6 1 DMTF1 1 CCND2 0 1.316762e-03 0.996774 0.6
      • regulation of cyclin-dependent protein serine/threonine kinase activity
      • cell cycle
      • cell division
      bioplex,mentha,string_0.9 cluster_clusterone_c0502_n33_e503 33 503 1 COL24A1 6 COL10A1, COL3A1, COL4A1, COL4A2, COL5A2, COL5A3 0 8.836109e-08 1.13627e-09 0.9527
      • collagen catabolic process
      • extracellular matrix disassembly
      • extracellular matrix organization
      bioplex,mentha,string_0.9 cluster_clusterone_c0515_n11_e34 11 34 1 JUP 5 DSC2, DSG2, DSP, JUP, PKP2 0 8.970798e-08 0.999966 0.6182
      • desmosome organization
      • regulation of heart rate by cardiac conduction
      • cardiac muscle cell action potential
      bioplex,mentha,string_0.9 cluster_clusterone_c0539_n15_e65 15 65 1 PER3 1 PER1 0 1.280449e-02 0.999589 0.619
      • circadian rhythm
      • rhythmic process
      • negative regulation of glucocorticoid receptor signaling pathway
      bioplex,mentha,string_0.9 cluster_clusterone_c0703_n16_e74 16 74 3 EFNB2, EPHA4, EPHB2 0 0 7.790938e-04 0.999869 0.6167
      • transmembrane receptor protein tyrosine kinase signaling pathway
      • nervous system development
      • peptidyl-tyrosine phosphorylation
      bioplex,mentha,string_0.9 cluster_clusterone_c0997_n4_e4 4 4 2 PCDH12, PCDH17 0 0 7.961768e-04 0.990291 0.6667

        Clusters in input/panel gene networks

        Visualization Network ID Nodes Edges Input nodes Input genes Panel nodes Panel genes Categories p-value ClusterONE p-value ClusterONE density Top enrichment
        funsimbp filtered_n299_e647_i-p_cluster_clusterone_c0002_n14_e46 14 46 9 FOXL1, GNRH1, LHX4, NPAS1, NR2F1, WWC1, ZNF117, ZNF300, ZNF83 5 FOS, SNAI3, SP1, TDG, TET1 0 1.000000e+00 0.0279689 0.5055
        • regulation of transcription, DNA-templated
        • transcription, DNA-templated
        • regulation of gene expression
        funsimbp filtered_n299_e647_i-p_cluster_clusterone_c0003_n4_e3 4 3 3 CDKL2, CSF3, NOX4 1 TGFB1 0 1.000000e+00 0.267852 0.5
        • protein kinase B signaling
        • regulation of actin cytoskeleton reorganization
        • cellular response to lipopolysaccharide
        funsimbp filtered_n299_e647_i-p_cluster_clusterone_c0004_n4_e3 4 3 3 EPHB2, NME5, SEMA3D 1 ANGPTL4 0 1.000000e+00 0.14407 0.5
          funsimbp filtered_n299_e647_i-p_cluster_clusterone_c0005_n4_e3 4 3 4 ABCB1, FABP4, GABRE, TMC3 0 0 1.000000e+00 0.14407 0.5
            funsimbp filtered_n299_e647_i-p_cluster_clusterone_c0006_n4_e3 4 3 3 FHL1, IFNE, SLC9A3R2 1 BCL2 0 1.000000e+00 0.434331 0.5
              funsimbp filtered_n299_e647_i-p_cluster_clusterone_c0007_n5_e5 5 5 4 CD79B, CD83, IFITM1, IFNE 1 GATA3 0 1.000000e+00 0.414406 0.5
              • response to interferon-alpha
              • immune response
              funsimbp filtered_n299_e647_i-p_cluster_clusterone_c0008_n4_e3 4 3 1 NEIL1 3 MCL1, SIRT1, TDG 0 1.000000e+00 0.851258 0.5
              • cellular response to DNA damage stimulus
              • nucleotide-excision repair
              • DNA repair
              funsimbp filtered_n299_e647_i-p_cluster_clusterone_c0009_n4_e3 4 3 1 CD74 3 IL32, MTOR, PIK3CG 0 1.000000e+00 0.975734 0.5
                funsimbp filtered_n299_e647_i-p_cluster_clusterone_c0010_n13_e36 13 36 3 COL6A6, ICAM2, ITGA10 10 CD44, COL10A1, COL1A1, COL3A1, COL5A2, COL5A3, ITGA6, ITGB1, LAMC2, NID1 0 1.000000e+00 0.0175895 0.4615
                • extracellular matrix organization
                • extracellular matrix disassembly
                • collagen catabolic process
                funsimbp filtered_n299_e647_i-p_cluster_clusterone_c0011_n5_e5 5 5 3 GSAP, HMSD, PABPC1L 2 APP, BACE1 0 1.000000e+00 0.335201 0.5
                • mRNA polyadenylation
                • beta-amyloid metabolic process
                • proteolysis
                funsimbp filtered_n299_e647_i-p_cluster_clusterone_c0012_n5_e5 5 5 3 GREM1, KREMEN1, MMRN2 2 CDC42, DES 0 1.000000e+00 0.773951 0.5
                  funsimbp filtered_n299_e647_i-p_cluster_clusterone_c0013_n4_e3 4 3 1 DMTF1 3 CDK6, TET1, TET2 0 1.000000e+00 0.949204 0.5
                  • oxidative DNA demethylation
                  • protein O-linked glycosylation
                  • DNA demethylation
                  funsimbp filtered_n299_e647_i-p_cluster_clusterone_c0014_n8_e14 8 14 2 COL24A1, SPEG 6 CCND2, LOX, PDGFB, PDGFRA, TGFB1, TGFB2 0 1.000000e+00 0.756642 0.5
                    funsimbp filtered_n299_e647_i-p_cluster_clusterone_c0015_n8_e16 8 16 3 CDH10, JUP, SYNC 6 CTNNA3, DSC2, DSG2, DSP, JUP, PKP2 0 1.000000e+00 0.0118485 0.5714
                    • regulation of heart rate by cardiac conduction
                    • cardiac muscle cell action potential
                    • desmosome organization
                    funsimbp filtered_n299_e647_i-p_cluster_clusterone_c0016_n4_e3 4 3 3 DIRAS3, F2RL1, FGF7 1 NKIRAS2 0 1.000000e+00 0.732148 0.5
                    • small GTPase mediated signal transduction
                    funsimbp filtered_n299_e647_i-p_cluster_clusterone_c0017_n6_e8 6 8 6 ADCY4, EDNRA, GABBR1, GNG11, HTR2A, RXFP1 0 0 1.000000e+00 0.0434913 0.5333
                    • G-protein coupled receptor signaling pathway
                    • activation of phospholipase C activity
                    • cAMP biosynthetic process
                    funsimbp filtered_n299_e647_i-p_cluster_clusterone_c0018_n9_e19 9 19 7 ABCC3, ATP8A1, ESYT3, GPM6B, RAB38, SEC31B, TMC3 2 NASP, PIK3R1 0 1.000000e+00 0.0120418 0.5278
                    • transport
                    funsimbp filtered_n299_e647_i-p_cluster_clusterone_c0019_n4_e3 4 3 2 KREMEN1, SEMA7A 2 ADAM12, GSK3B 0 1.000000e+00 0.892262 0.5
                      funsimbp filtered_n299_e647_i-p_cluster_clusterone_c0020_n4_e3 4 3 4 BIRC3, CD74, HTR2A, TNFRSF10C 0 0 1.000000e+00 0.892262 0.5
                        funsimbp filtered_n299_e647_i-p_cluster_clusterone_c0021_n10_e23 10 23 1 COL6A6 9 COL10A1, COL1A1, COL3A1, COL4A1, COL4A2, COL5A2, COL5A3, MMP15, MMP2 0 1.000000e+00 0.0589289 0.5111
                        • collagen catabolic process
                        • extracellular matrix disassembly
                        • extracellular matrix organization
                        funsimbp filtered_n299_e647_i-p_cluster_clusterone_c0023_n10_e23 10 23 9 ABCC3, ABCG1, ATP8A1, ESYT3, GPM6B, RAB38, SEC31B, SLCO2B1, TMC3 1 NASP 0 1.000000e+00 0.0257381 0.5111
                        • lipid transport
                        • transport
                        • ion transport
                        funsimbp filtered_n299_e647_i-p_cluster_clusterone_c0024_n4_e3 4 3 2 BIRC3, TNFRSF10C 2 ESR1, NCOA3 0 1.000000e+00 0.949204 0.5
                        • vagina development
                        • cellular response to estrogen stimulus
                        • tumor necrosis factor-mediated signaling pathway
                        funsimbp filtered_n299_e647_i-p_cluster_clusterone_c0025_n5_e5 5 5 1 DMTF1 4 CCND2, CDK6, HMGA2, TET2 0 1.000000e+00 0.988183 0.5
                        • cell cycle
                        funsimbp filtered_n299_e647_i-p_cluster_clusterone_c0026_n8_e14 8 14 3 COL24A1, CRYGS, LRRC32 5 LOX, PPP1R13B, TGFB1, TGFB2, TGFB3 0 1.000000e+00 0.727709 0.5
                        • negative regulation of macrophage cytokine production
                        • positive regulation of pathway-restricted SMAD protein phosphorylation
                        • SMAD protein import into nucleus
                        funsimbp filtered_n299_e647_i-p_cluster_clusterone_c0028_n4_e3 4 3 1 DCLK1 3 DUSP2, PTEN, S100B 0 1.000000e+00 0.814074 0.5
                          funsimbp filtered_n299_e647_i-p_cluster_clusterone_c0029_n11_e29 11 29 6 DOCK6, FGF7, KIAA1217, MMRN2, PGF, SH2D2A 5 PDGFA, PDGFB, PDGFC, PDGFRA, PDGFRB 0 1.000000e+00 0.0127596 0.5273
                          • transmembrane receptor protein tyrosine kinase signaling pathway
                          • activation of protein kinase activity
                          • small GTPase mediated signal transduction
                          funsimbp filtered_n299_e647_i-p_cluster_clusterone_c0030_n4_e3 4 3 3 KRT17, MATR3, SYNC 1 EIF4G1 0 1.000000e+00 0.440467 0.5
                          • posttranscriptional regulation of gene expression
                          funsimbp filtered_n299_e647_i-p_cluster_clusterone_c0031_n4_e3 4 3 3 GUCY1A2, KLF5, SPEG 1 VEGFA 0 1.000000e+00 0.937953 0.5
                            funsimbp filtered_n299_e647_i-p_cluster_clusterone_c0033_n4_e3 4 3 1 MATR3 3 AKT2, EIF4G1, PPP1R13B 0 1.000000e+00 0.907062 0.5
                              funsimbp filtered_n299_e647_i-p_cluster_clusterone_c0034_n4_e3 4 3 2 FOXS1, NEIL1 2 MCL1, SIRT1 0 1.000000e+00 0.937953 0.5
                                funsimbp filtered_n299_e647_i-p_cluster_clusterone_c0035_n11_e28 11 28 4 DOCK6, FGF7, KIAA1217, SH2D2A 7 LOX, NKIRAS2, PDGFA, PDGFB, PDGFC, PDGFRA, PDGFRB 0 1.000000e+00 0.00877207 0.5091
                                • small GTPase mediated signal transduction
                                • activation of protein kinase activity
                                • Fc-epsilon receptor signaling pathway
                                funsimbp filtered_n299_e647_i-p_cluster_clusterone_c0036_n6_e8 6 8 6 C5, CCRL2, CXCL12, EDNRA, F2RL1, RXFP1 0 0 1.000000e+00 0.467403 0.5333
                                • G-protein coupled receptor signaling pathway
                                funsimbp filtered_n299_e647_i-p_cluster_clusterone_c0039_n4_e3 4 3 1 CPM 3 GPC3, MMP15, MMP2 0 1.000000e+00 0.437184 0.5
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